Ethanol → HCID 14626284, compound

Participants

Reaction Conditions

Reaction Steps

To 50 g of phosphorus pentoxide is slowly added 30 ml of ethanol at room temperature and the mixture is further stirred with heating at 100° C. for 1 hour. Thereto 10 g of 2-[(2,5-dimethyoxyphenyloxy)methyl]benzoic acid is added and the mixture is stirred at 100° C. for 1 hour. After cooling to room temperature, the mixture is added with 300 ml of water and extracted with toluene. After the extract is successively washed with a saturated solution of sodium hydrogen carbonate, water and a saturated saline solution and dried over magnesium sulfate, the solvent is distilled off under reduced pressure to give 7 g of 1,4-dimethoxy-6,11-dihydrodibenz[b,e]oxepin-11-one (oil). Mass spectrum m/z: 270(M+).

Provenance & Evidence