Piperazine → HCID 14626286, compound

Participants

Reaction Steps

To a solution of 15 g of 11-chloro-2-fluoro-6,11-dihydrodibenz[b,e]oxepin, which is prepared according to the procedure of Reference Example 1, in 300 ml of chloroform is added a solution of 25 g of anhydrous piperazine in 50 ml of chloroform at 0° C. After the temperature of the reaction mixture is raised to room temperature over 2 hours, it is added with 10% aqueous sodium hydroxide and extracted with chloroform. After the extract is washed with a saturated saline solution and dried over anhydrous potassium carbonate, the solvent is distilled off under reduced pressure. After the residue is added with 500 ml of toluene, an excess amount of piperazine is distilled off under reduced pressure to give 12 g of the objective compound as an oil. Mass spectrum m/z:298(M+).

Provenance & Evidence