Water → HCID 19913682, compound

Participants

Reaction Steps

1.26 g of 4-[(10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-pyrido[2,1-a]phthalazin-1-yl)carbonyl]morpholine are dissolved in 30 ml of dichloromethane under argon, whereupon 1.01 g of tetrabutylammonium hydrogen sulfate, 1.4 g of ethyl iodide and 1.45 ml of 50 percent sodium hydroxide solution are added thereto and the mixture is stirred at room temperature until the reaction has finished. Three (3) ml of water are added thereto. The organic phase is separated and dried, and the solvent is removed in vacuo. The residue is chromatographed on silica gel. After recrystallization there is obtained 4-[(6-ethyl-10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-pyrido[2,1-a]phthalazin-1-yl)carbonyl]morpholine as yellow crystals of m.p. 288°-289° (acetonitrile).

Provenance & Evidence