Ethanol → HCID 19834996, compound

HRID 477814Notes

Reaction equation

HRID 477814 reaction equation
[ClH:1].Cl.[CH2:3]([N:10]([CH2:12][CH:13]1[O:18][CH2:17][CH2:16][N:15](CC2C=CC=CC=2)[CH2:14]1)C)C1C=CC=CC=1.C(O)C>[C].[Pd].O>[OH2:18].[ClH:1].[ClH:1].[CH3:3][NH:10][CH2:12][CH:13]1[O:18][CH2:17][CH2:16][NH:15][CH2:14]1

Participants

5

Reactant 2

HCID 702EthanolHCID 19834979HCID 19834979, compound

Product 1

HCID 19834996HCID 19834996, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 962WaterSolvent

Procedure

A mixture of 58 g of 2-chloromethyl-4-benzylmorpholine, 62.3 g of N-benzyl-N-methylamine and 38.6 g of sodium iodide in 220 ml of dimethylformamide is refluxed under stirring at 140° C. for 6 hours. After completion of the reaction, the dimethylformamide is distilled off under reduced pressure, water is added to the residue and the mixture is subjected to extraction with ethyl acetate. After washing with water, the resultant mixture is dried over anhydrous magnesium sulfate and the solvent is distilled off under reduced pressure. The residue is treated in 37% hydrochloric acid-ethanol to give 2-(N-benzyl-N-methylaminomethyl)-4-benzylmorpholine dihydrochloride as white crystals. The obtained hydrochloride compound (29.7 g) is subjected to catalytic reduction with 50 ml of ethanol, 80 ml of water and 3 g of 10% palladium-carbon. After absorbing the theoretical volume of the hydrogen, the catalyst is filtered off and the solvent of the filtrate is distilled off to give 2-(methylaminomethyl)morpholine dihydrochloride monohydrate as white crystals, melting at 122°-124° C.

Workup

  1. customAfter absorbing the theoretical volume of the hydrogen
  2. filtrationthe catalyst is filtered off
  3. distillationthe solvent of the filtrate is distilled off

Sources & evidence

ORD record
ord-688b0f1328884bbeb13b6ab7de1dfa07
Source dataset
uspto-grants-1989_12
Patent number
US04889857

Reaction notes

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