1-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → HCID 19834997, compound

HRID 477834Notes

Reaction equation

HRID 477834 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:15])=[C:10](F)[C:11]=2[F:13])[C:6](=[O:16])[C:5]([C:17]([OH:19])=[O:18])=[CH:4]1)[CH3:2].[CH3:20][CH:21]1[CH2:26][NH:25][CH2:24][CH:23]([CH2:27][NH:28][CH3:29])[O:22]1>>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:15])=[C:10]([N:25]3[CH2:26][CH:21]([CH3:20])[O:22][CH:23]([CH2:27][NH:28][CH3:29])[CH2:24]3)[C:11]=2[F:13])[C:6](=[O:16])[C:5]([C:17]([OH:19])=[O:18])=[CH:4]1)[CH3:2]

Participants

3

Reactant 2

HCID 98351791-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acidHCID 19834988HCID 19834988, compound

Product 1

HCID 19834997HCID 19834997, compound

Procedure

By the use of 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid and 6-methyl-2-(methylaminomethyl)morpholine, the reaction is similarly carried out as Example 1 to give 1-ethyl-6,8-difluoro-1,4-dihydro-7-[6-methyl-2-(methylaminomethyl)morpholino]-4-oxoquinoline-3-carboxylic acid.

Sources & evidence

ORD record
ord-fced60a6655d43c49a368e129c7852d8
Source dataset
uspto-grants-1989_12
Patent number
US04889857

Reaction notes

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