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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 477840Generated: October 26, 2026

1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → 1-Cyclopropyl-6,8-difluoro-7-[2-(formylaminomethyl)morpholino]-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

https://huagongshe.com/reaction/477840

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acidHCID 535414—
Reactant2-(Formylaminomethyl)morpholineHCID 19834981—
Product1-Cyclopropyl-6,8-difluoro-7-[2-(formylaminomethyl)morpholino]-1,4-dihydro-4-oxoquinoline-3-carboxylic acidHCID 14652606—

Reaction Steps

By the use of 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid and 2-(formylaminomethyl)morpholine, the reaction is similarly carried out as Example 11 to give 1-cyclopropyl-6,8-difluoro-7-[2-(formylaminomethyl)morpholino]-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, melting at 210°-213° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04889857
Source datasetuspto-grants-1989_12
ORD IDord-7c39efc87e0d481881e894b591db23bb
Source noteuspto-grants-1989_12