HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → 1-Cyclopropyl-7-[2-(dimethylaminomethyl)morpholino]-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 535414 | — |
| Reactant | Dimethyl-morpholin-2-ylmethyl-amine | HCID 3401489 | — |
| Product | 1-Cyclopropyl-7-[2-(dimethylaminomethyl)morpholino]-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 10454056 | — |
Reaction Steps
By the use of 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid and 2-(dimethylaminomethyl)morpholine, the reaction is similarly carried out as Example 1 to give 1-cyclopropyl-7-[2-(dimethylaminomethyl)morpholino]-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, melting at 182°-183° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04889857 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-a59dfd2d09974ac0be9401af878d1de9 |
| Source note | uspto-grants-1989_12 |