1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → 1-Cyclopropyl-7-[2-(2-ethylaminoethyl)morpholino]-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

HRID 477848Notes

Reaction equation

HRID 477848 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10](F)=[C:11](F)[C:12]=3F)[C:7](=[O:17])[C:6]([C:18]([OH:20])=[O:19])=[CH:5]2)[CH2:3][CH2:2]1.[CH2:21]([NH:23][CH2:24][CH2:25][CH:26]1[O:31][CH2:30][CH2:29][NH:28][CH2:27]1)[CH3:22]>>[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][CH:10]=[C:11]([N:28]4[CH2:29][CH2:30][O:31][CH:26]([CH2:25][CH2:24][NH:23][CH2:21][CH3:22])[CH2:27]4)[CH:12]=3)[C:7](=[O:17])[C:6]([C:18]([OH:20])=[O:19])=[CH:5]2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 5354141-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acidHCID 19834963HCID 19834963, compound

Product 1

HCID 198349861-Cyclopropyl-7-[2-(2-ethylaminoethyl)morpholino]-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Procedure

By the use of 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid and 2-(2-ethylaminoethyl)morpholine, the reaction is similarly carried out as Example 11 to give 1-cyclopropyl-7-[2-(2-ethylaminoethyl)morpholino] -1,4-dihydro-4-oxoquinoline-3-carboxylic acid.

Sources & evidence

ORD record
ord-280573efbca74945b88bf86363e71386
Source dataset
uspto-grants-1989_12
Patent number
US04889857

Reaction notes

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