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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 477850Generated: October 31, 2026

N-((Morpholin-2-YL)methyl) ethanamine → 7-[2-(Ethylaminomethyl)morpholino]-1(2,4-difluorophenyl)-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

https://huagongshe.com/reaction/477850

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-((Morpholin-2-YL)methyl) ethanamineHCID 10351814—
Reactant1-(2,4-Difluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acidHCID 14476011—
Product7-[2-(Ethylaminomethyl)morpholino]-1(2,4-difluorophenyl)-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acidHCID 14652610—

Reaction Steps

By the use of 1-(2,4-difluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid and 2-(ethylaminomethyl)morpholine, the reaction is similarly carried out as Example 26 to give 7-[2-(ethylaminomethyl)morpholino]-1(2,4-difluorophenyl)-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, melting at 226°-229° C. with decomposition. Examle 28

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04889857
Source datasetuspto-grants-1989_12
ORD IDord-9455349a3e474b38ab46a7c1b96f9ddb
Source noteuspto-grants-1989_12