HCID 14476011, compound → HCID 14652611, compound

HRID 477851Notes

Reaction equation

HRID 477851 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:18]2[C:13](=[CH:14][C:15]([F:21])=[C:16](F)[C:17]=2[F:19])[C:12](=[O:22])[C:11]([C:23]([OH:25])=[O:24])=[CH:10]1.[CH:26]([NH:28][CH2:29][CH:30]1[O:35][CH2:34][CH2:33][NH:32][CH2:31]1)=[O:27]>>[F:19][C:17]1[CH:16]=[C:15]([F:21])[CH:14]=[CH:13][C:18]=1[N:9]1[C:3]2[C:4](=[CH:5][C:6]([F:8])=[C:7]([N:32]3[CH2:33][CH2:34][O:35][CH:30]([CH2:29][NH:28][CH:26]=[O:27])[CH2:31]3)[C:2]=2[F:1])[C:12](=[O:22])[C:11]([C:23]([OH:25])=[O:24])=[CH:10]1

Participants

3

Reactant 2

HCID 14476011HCID 14476011, compoundHCID 198349812-(Formylaminomethyl)morpholine

Product 1

HCID 14652611HCID 14652611, compound

Procedure

By the use of 1-(2,4-difluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid and 2-(formylaminomethyl)morpholine, the reaction is similarly carried out as Example 26 to give 1-(2,4-difluorophenyl)-6,8-difluoro-7-[2-(formylaminomethyl)morpholino]-1,4-dihydro-4-oxoquinoline- 3-carboxylic acid, melting at 230°-233° C. with decomposition.

Sources & evidence

ORD record
ord-d135832f112c454e9f2d3c0bbd85308b
Source dataset
uspto-grants-1989_12
Patent number
US04889857

Reaction notes

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