1-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → HCID 19834959, compound

HRID 477860Notes

Reaction equation

HRID 477860 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:15])=[C:10](F)[C:11]=2[F:13])[C:6](=[O:16])[C:5]([C:17]([OH:19])=[O:18])=[CH:4]1)[CH3:2].[NH2:20][CH2:21][CH:22]1[CH2:27][O:26][CH2:25][CH2:24][NH:23]1>>[NH2:20][CH2:21][CH:22]1[N:23]([C:10]2[C:11]([F:13])=[C:12]3[C:7]([C:6](=[O:16])[C:5]([C:17]([OH:19])=[O:18])=[CH:4][N:3]3[CH2:1][CH3:2])=[CH:8][C:9]=2[F:15])[CH2:24][CH2:25][O:26][CH2:27]1

Participants

3

Reactant 2

HCID 98351791-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acidHCID 190451891-(Morpholin-3-yl)methanamine

Product 1

HCID 19834959HCID 19834959, compound

Procedure

By the use of 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid and 3-(aminomethyl)morpholine, the reaction is similarly carried out as Example 1 to give 7-[3-(aminomethyl)morpholino]-1-ethyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid.

Sources & evidence

ORD record
ord-48aec4f65ff1457e8c1b4be0a4c4f5a7
Source dataset
uspto-grants-1989_12
Patent number
US04889857

Reaction notes

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