1-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → HCID 19834957, compound

HRID 477861Notes

Reaction equation

HRID 477861 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:15])=[C:10](F)[C:11]=2[F:13])[C:6](=[O:16])[C:5]([C:17]([OH:19])=[O:18])=[CH:4]1)[CH3:2].[CH3:20][NH:21][CH2:22][CH:23]1[CH2:28][O:27][CH2:26][CH2:25][NH:24]1>>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:15])=[C:10]([N:24]3[CH2:25][CH2:26][O:27][CH2:28][CH:23]3[CH2:22][NH:21][CH3:20])[C:11]=2[F:13])[C:6](=[O:16])[C:5]([C:17]([OH:19])=[O:18])=[CH:4]1)[CH3:2]

Participants

3

Reactant 2

HCID 98351791-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acidHCID 19835000HCID 19835000, compound

Product 1

HCID 19834957HCID 19834957, compound

Procedure

By the use of 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid and 3-(methylaminomethyl)morpholine, the reaction is similarly carried out as Example 1 to give 1-ethyl-6,8-difluoro-1,4-dihydro-7-[3-(methylaminomethyl)morpholino]-4-oxoquinoline-3-carboxylic acid.

Sources & evidence

ORD record
ord-5856e8f39f0049848c987c2c25dc8b08
Source dataset
uspto-grants-1989_12
Patent number
US04889857

Reaction notes

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