Hydrochloric Acid → HCID 14652600, compound

Participants

Reaction Steps

A solution of 4.93 g of ethyl 1-cyclopropyl-6,8-difluoro-7-[2-(N-ethoxycarbonyl-N-methylaminomethyl)morpholino]-1,4-dihydro-4-oxoquinoline-3-carboxylate obtained by Example 49(1), 5 ml of 18% aqueous hydrochloric acid in 50 ml of ethanol is refluxed for 7 hours. The reaction mixture is concentrated under reduced pressure, to the obtained residue is added 50 ml of chloroform and the solution is washed with water. After drying over anhydrous magnesium sulfate, the chloroform is distilled off under reduced pressure and the obtained crystals are recrystallized from a mixed solvent of ethyl acetate and isopropyl ether to give 3.53 g of 1-cyclopropyl-6,8-difluoro-7-[2-(N-ethoxycarbonyl-N-methylaminomethyl)morpholino]-1,4-dihydro-4-oxoquinoline-3-carboxylic acid in 76% yield, melting at 128°-131° C.

Provenance & Evidence