Dimethylformamide → HCID 14178554, compound

Participants

Reaction Steps

A mixture of 4-(2-chlorophenyl)-3-(4-hydroxyphenyl)sulfonyl-5-methoxycarbonyl-2,6-dimethyl-1,4-dihydropyridine (4.33 g), potassium carbonate (2.76 g), methyl iodide (5.68 g), and N,N-dimethylformamide (DMF) (25 ml) was stirred at room temperature for 24 hours. The reaction mixture was diluted with water (250 ml) and extracted with ethyl acetate. The extract was dried over magnesium sulfate, filtered, and evaporated to dryness. The residue was crystallized from ether to give 4-(2-chlorophenyl)-3-(4-methoxyphenyl)sulfonyl-5-methoxycarbonyl-2,6-dimethyl-1,4-dihydropyridine, m.p. 176°-178°.

Provenance & Evidence