HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 7-oxo-8-phenyl-7H-thieno[2,3-a]quinolizine-10-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | methyl 7-oxo-8-phenyl-7H-thieno[2,3-a]quinolizine-10-carboxylate | HCID 14666705 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | 7-oxo-8-phenyl-7H-thieno[2,3-a]quinolizine-10-carboxylic acid | HCID 14666743 | — |
Reaction Steps
(aa) 1.34 g of methyl 7-oxo-8-phenyl-7H-thieno[2,3-a]quinolizine-10-carboxylate were heated under reflux and under argon with 0.45 g of potassium hydroxide in 25 ml of water/methanol. After the reaction was completed, the mixture was acidified with 2N hydrochloric acid and the yellow crystals were removed by filtration. After washing with water, the acid was dried in vacuo for several hours. There was obtained 7-oxo-8-phenyl-7H-thieno[2,3-a]quinolizine-10-carboxylic acid of m.p. 185°-186° (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04889848 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-dd216b0cb3a3445e84bda82db421191e |
| Source note | uspto-grants-1989_12 |