Lithium Hydroxide → HCID 23431214, compound

Participants

Reaction Steps

A solution of 3-[4-(2-{[(2,4-difluoro-phenyl)-acetyl]-heptyl-amino}-ethyl)-phenyl]-2-ethoxy-propionic acid methyl ester (35 mg, 0.07 mmol) and 1 M LiOH (0.208 mmol, 0.208 mL) in tetrahydrofuran (1 mL) was allowed to stir at room temperature for 78 hours. 2 N HCL was added until the solution had a pH<2. After dilution with twice its volume in water, the aqueous layer was extracted with diethyl ether (2×). The organic layers were combined, washed with 2M HCl (2×), dried over anhydrous sodium sulfate, and concentrated to give 3-[4-(2-{[(2,4-difluoro-phenyl)-acetyl]-heptyl-amino}-ethyl)-phenyl]-2-ethoxy-propionic acid as a clear oil (28.6 mg, 84%).

Provenance & Evidence