反应详情

A solution of 4.5 g of 4-[4-(p-tert-butylaminocarbonylphenyl)-4-hydroxy-n-butyl]-1-trimethylsilylimidazole in 50 ml of thionyl chloride is refluxed for 1 h, cooled and evaporated. The residue is partitioned between methylene chloride and aqueous sodium bicarbonate solution. The organic phase is separated, dried over sodium sulfate and evaporated to yield the title compound (c).

1. temperaturecooled
2. customevaporated
3. customThe residue is partitioned between methylene chloride and aqueous sodium bicarbonate solution
4. customThe organic phase is separated
5. dry with materialdried over sodium sulfate
6. customevaporated