反应详情

A solution of 1.18 g or 5-(p-ethoxycarbonylphenyl)imidazo[1,5-a]pyridine in 10 ml of ethanol and 14 ml of 1N sodium hydroxide solution is refluxed for 3 h, cooled and evaporated. The residue is partitioned between water and ethyl acetate. The aqueous phase is separated and adjusted to pH 5. The solid is filtered, washed with water and dried to yield the title compound, m.p. 308°-310° (dec.).

1. temperaturecooled
2. customevaporated
3. customThe residue is partitioned between water and ethyl acetate
4. customThe aqueous phase is separated
5. filtrationThe solid is filtered
6. washwashed with water
7. customdried