反应详情

温度

40 °C

Methyl 7-[[5-(4-acetyl-3-hydroxy-2-propylphenoxy)pentyl]oxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylate (1 mMol), prepared as described in U.S. Pat. No. 4,565,882, was dissolved in acetone containing 2.5 equivalents of potassium hydroxide and 3 equivalents of dimethyl sulfate. The mixture was heated at 40° C. for 10 hours and then cooled; the solvent was removed in vacuo and the residue partitioned between ethyl acetate and water. The organic layer was separated and dried over magnesium sulfate. Evaporation of the volatiles in vacuo afforded the methyl ether.

1. temperaturecooled
2. customthe solvent was removed in vacuo
3. customthe residue partitioned between ethyl acetate and water
4. customThe organic layer was separated
5. dry with materialdried over magnesium sulfate
6. customEvaporation of the volatiles in vacuo