Lithium Hydroxide → HCID 23431239, compound

Participants

Reaction Steps

A solution of 2-ethoxy-3-{4-[2-(1-heptyl-3-methyl-3-phenyl-ureido)-ethyl]-phenyl}-propionic acid methyl ester (98 mg, 0.20 mmol) and 1 M LiOH (0.60 mmol, 0.60 mL) in tetrahydrofuran (1 mL) was allowed to stir at room temperature for 16 hours. 2 N HCL was then added until the solution had a pH<2. After dilution with twice its volume in water, the aqueous layer was extracted with diethyl ether (2×). The organic layers were combined, washed with 2 M HCl (2×), dried over anhydrous sodium sulfate, and concentrated to give 2-ethoxy-3-{4-[2-(1-heptyl-3-methyl-3-phenyl-ureido)-ethyl]-phenyl}-propionic acid as a clear oil (73 mg, 78%).

Provenance & Evidence