Hydrochloric Acid → (S)-2-amino-4-cyclohexylbutanoic acid

Participants

Reaction Steps

896 mg of L-homophenylalanine (2(S)-amino-4-phenylbutyric acid) are hydrogenated in 25 ml of water and 5.5 ml of 1N HCl in the presence of 18 mg of Nishimura catalyst (rhodium oxide/platinum oxide). The reaction mixture is filtered while warm. The title compound crystallises out of the filtrate in the form of white crystals after the addition of 5.5 ml of 1N NaOH. M.p. 265°-266°; Rf (R)=0.09.

Provenance & Evidence