Water → HCID 178510894, compound

HRID 478061Notes

Reaction equation

HRID 478061 reaction equation
Cl[CH2:2][C:3]1[N:4]=[C:5]([OH:13])[C:6]2[S:12][CH2:11][CH2:10][CH2:9][C:7]=2[N:8]=1.[C-:14]#[N:15].[Na+].O>CS(C)=O>[C:14]([CH2:2][C:3]1[N:4]=[C:5]([OH:13])[C:6]2[S:12][CH2:11][CH2:10][CH2:9][C:7]=2[N:8]=1)#[N:15]

Participants

5

Reactant 3

HCID 962WaterHCID 8929Sodium CyanideHCID 178517759HCID 178517759, compound

Product 1

HCID 178510894HCID 178510894, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
25 °C

Procedure

Product from Example 3, step A, (1.8 g, 0.01 mol) was dissolved in 10 ml of DMSO and sodium cyanide (1.0 g) was added. The reaction mixture was stirred at 25° C. for 3.5 hours and then poured into water (150 ml). The solution was extracted with ethyl acetate, the ethyl acetate was dried and then evaporated to give the title compound as an oil that was used directly in Step B hereof.

Workup

  1. extractionThe solution was extracted with ethyl acetate
  2. dry with materialthe ethyl acetate was dried
  3. customevaporated

Sources & evidence

ORD record
ord-306dea289e114e10bbbfcfdb59e49f6d
Source dataset
uspto-grants-1989_12
Patent number
US04889856

Reaction notes

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