HCID 178437761, compound → HCID 178437758, compound

Participants

Reaction Steps

The aqueous filtrate was extracted with four 75 ml portions of chloroform. The organic extracts were washed once with brine, dried (MgSO4) and concentrated under vacuum. The residual oil was diluted with ether (15 ml) and hexane (15 ml). The solid that crystallized was filtered, washed with four 3 ml portions of ether and combined with the solid obtained earlier from the aqueous solution. The 2.3 g of colorless solid was shown by NMR in DMSO to be a 1:1 mixture of 2-ethyl-4-hydroxy-dihydrothieno-[3,2-d]pyrimidine and 2-ethyl-4-hydroxy-dihydrothieno-[3,4-d]pyrimidine.

Provenance & Evidence