Ethyl trifluoroacetate → HCID 86597433, compound

HRID 478120Notes

Reaction equation

HRID 478120 reaction equation
[CH2:1]([O:8][C:9](=[O:17])[C@H:10]([CH2:12][CH2:13][C:14]([OH:16])=[O:15])[NH2:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O:20][C:21](=O)[C:22]([F:25])([F:24])[F:23])C>C(O)C>[CH2:1]([O:8][C:9](=[O:17])[C@H:10]([CH2:12][CH2:13][C:14]([OH:16])=[O:15])[NH:11][C:21](=[O:20])[C:22]([F:25])([F:24])[F:23])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 9794Ethyl trifluoroacetateHCID 7009632(4S)-4-amino-5-benzyloxy-5-oxo-pentanoic acid

Product 1

HCID 86597433HCID 86597433, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

100 g (421.5 mmol) of L-glutamic acid-mono-benzyl ester is dissolved in a mixture that consists of 1000 ml of trifluoroacetic acid ethyl ester/500 ml of ethanol, and it is stirred for 24 hours at room temperature. It is evaporated to the dry state, and the residue is crystallized from diisopropyl ether.

Workup

  1. customIt is evaporated to the dry state
  2. customthe residue is crystallized from diisopropyl ether

Sources & evidence

ORD record
ord-85d3b19408e043de9bece49c216dc886
Source dataset
uspto-grants-2003_11
Patent number
US06641797B2

Reaction notes

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