Benzoyl chloride → HCID 8724770, compound

To a solution of the KSCN (4.60 g; 47.33 mmoL) in acetone (35 mL), at 0° C., was added dropwise benzoylchloride (5.0 mL; 43.03 mmoL). The milky solution was stirred in an ice bath for 1.5 h, then, cyclopropylamine (3.2 mL; 46.0 mmoL) was added dropwise. The reaction mixture was stirred for 1.5 h at 0° C., then, more cyclopropylamine (0.50 mL, 7.22 mmoL) was added and the reaction mixture stirred at R.T. for an additional 30 min. The reaction mixture was poured into ice/H2O (300 mL), stirred for 5 min. and the light yellow solid was filtered, washed several times with H2O and dried to provide N-benzyloxy-N′-cyclopropyl thiourea (6.62 g). This thiourea was suspended in a solution of 2N NaOH (50 mL) and heated at reflux for 15 min. The solution was cooled to R.T., saturated with solid NaCl and extracted with EtOAc (3×). The combined EtOAc extracts were washed with H2O (2×) and brine (1×), dried (MgSO4), filtered and evaporated to give the crude product as an off-white solid. The solid was triturated in hexane/EtOAc 5/5 to provide the N-cyclopropyl thiourea 8d as a white crystalline solid (2.5 g; 50% yield).

1. stirringThe reaction mixture was stirred for 1.5 h at 0° C.
2. stirringthe reaction mixture stirred at R.T. for an additional 30 min
3. stirringstirred for 5 min.
4. filtrationthe light yellow solid was filtered
5. washwashed several times with H2O
6. customdried

ORD record

ord-6df65a432e114c2388855216c64a9aa6

Source dataset

uspto-grants-2003_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06642204B2