HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[4-(1-Methylethyl)phenyl]-3-buten-2-ol → 3-[4-(1-Methylethyl)phenyl]-3-buten-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[4-(1-Methylethyl)phenyl]-3-buten-2-ol | HCID 18000877 | — |
| Catalyst | HCID 178418406 | HCID 178418406 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-[4-(1-Methylethyl)phenyl]-3-buten-2-one | HCID 18000858 | — |
Reaction Steps
2.75 g of alcohol 45 is dissolved in 300 ml of methylene chloride, and 25.1 g of manganese dioxide is added under nitrogen. It is stirred overnight at room temperature, filtered on Celite, and the residue is chromatographed on silica gel with ethyl acetate/hexane, whereby 937 mg of title compound 46 in addition to 635 mg of the starting material is obtained as colorless oils.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06642218B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-243eb4226a1b40639642a35f8bed5be2 |
| Source note | uspto-grants-2003_11 |