HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminopropanol → 1-Bromocyclopropanecarboxylic acid-2-hydroxy-1-methylethylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminopropanol | HCID 5126 | — |
| Reactant | 1-Bromocyclopropane-carboxylic acid chloride | HCID 10910206 | — |
| Reactant | (IR)-1-bromocyclopropanecarboxylic acid-2-hydroxy-1-phenylethylamide | HCID 21350875 | — |
| Product | 1-Bromocyclopropanecarboxylic acid-2-hydroxy-1-methylethylamide | HCID 18000851 | — |
Reaction Steps
Analogously to the production of amide 110, 2.18 g of acid chloride 107 is reacted with 780 mg of DL-2-amino-1-propanol, whereby 1.7 g of 1-bromocyclopropanecarboxylic acid-2-hydroxy-1-methylethylamide 112 is obtained as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06642218B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-ccb6727b4be241dd9f32c6df90210cd0 |
| Source note | uspto-grants-2003_11 |