HCID 18001130, compound → HCID 18001132, compound

Participants

Reaction Steps

A mixture of 2.14 g of 2′-hydroxy-4-(4-methyl-1,4-diazepan-1-yl)-6′-nitrobenzanilide, 43 ml of methanol and 467 mg of 10% palladium-carbon (wetting rate: 54.2%) was stirred in a hydrogen atmosphere of atmospheric pressure at 30° C. until the absorption of hydrogen had stopped. The catalyst was filtered out and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography using chloroform-methanol (20:1 to 10:1) to give 1.61 g of 2′-amino-6′-hydroxy-4-(4-methyl-1,4-diazepan-1-yl)benzanilide.

Provenance & Evidence