N-(3-chloropropyl)piperidine hydrochloride → HCID 70038547, compound

Participants

Reaction Steps

Using 4-(2-naphthyl)piperidine (167 mg, 0.67 mmol) and 1-(3-chloropropyl)piperidine hydrochloride (198 mg, 1.0 mmol) instead of 4-(3-indolyl)piperidine and 3-dimethylaminopropyl chloride hydrochloride respectively, reaction, extraction, and concentration were carried out in the same procedure as Example 4. The resulting crude product was purified by column chromatography on a silica gel (silica gel NH-DM 1020 produced by Fuji Silysia Chemical Ltd., eluent; hexane:chloroform=1:1) to afford a free form (187 mg) of the title compound as a yellow viscous oil. After adding hydrochloric acid/methanol to a solution of the free form in methanol, the mixture was concentrated and was then recrystallized from ethanol to afford the title compound (177 mg, yield: 64%) as white crystals.

Provenance & Evidence