3-Bromoimidazo(1,2-a)pyrimidine → 3'-(Imidazo[1,2-a]pyrimidin-3-yl)biphenyl-2-carbonitrile

Participants

Reaction Steps

3-Bromoimidazo[1,2-a]pyrimidine (0.29 g, 1.68 mmol) was coupled with 3′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile as described in Example 1 to give 3′-(imidazo[1,2-a]pyrimidin-3-yl)biphenyl-2-carbonitrile (260 mg, 60%) as an off-white powder: δH (360 MHz, CDCl3) 6.97 (1H, dd, J 7 and 4), 7.51 (1H, td, J 1 and 8), 7.59 (1H, dd, J 7 and 1), 7.62-7.73 (4H, m), 7.77-7.78 (1H, m), 7.82 (1H, dd, J 8 and 1), 7.96 (1H, s), 8.60 (1H, dd, J 7 and 2), 8.98 (1H, d, J 7 and 2); m/z (ES+) 297 (M++H).

Provenance & Evidence