HRID47822

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7509

Benzenemethanethiol

C7H8S

结构：CCCCCCCN(CCc1ccc(CC(O)C(=O)OCC)cc1)C(=O)OC(C)(C)C

HCID69883772

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCN(CCc1ccc(CC(SCc2ccccc2)C(=O)OCC)cc1)C(=O)OC(C)(C)C

HCID69884409

未命名化合物

PROCEDURE

实验过程

Synthesized from 3-{4-[2-(tert-butoxycarbonyl-heptyl-amino)-ethyl]-phenyl}-2-hydroxy-propionic acid ethyl ester using a procedure analogous to that used for Example 50 and substituting benzylthiol as the nucleophile to give an approximate 1:1 mixture of ethyl and methyl ester as a clear film (58 mg, 95%).

WORKUP

后处理

customto give

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c27f4f61df394971ac1b20ed531d0237
来源数据集: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06699904B2
来源说明: uspto-grants-2004_03

反应 SMILES

[CH2:1]([O:3][C:4](=[O:31])[CH:5](O)[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][N:15]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:9][CH:8]=1)[CH3:2].[CH:32]1[CH:37]=[CH:36][C:35]([CH2:38][SH:39])=[CH:34][CH:33]=1>>[CH2:1]([O:3][C:4](=[O:31])[CH:5]([S:39][CH2:38][C:35]1[CH:36]=[CH:37][CH:32]=[CH:33][CH:34]=1)[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][N:15]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:9][CH:8]=1)[CH3:2]