HuagongsheHuagongshe Chemistry Print Report · For research reference only
3'-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile → 3-(7-Trifluoromethylimidazo[1,2-a]pyrimidin-3-yl)biphenyl-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3'-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile | HCID 11243655 | — |
| Reactant | 3-Bromo-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine | HCID 11391462 | — |
| Product | 3-(7-Trifluoromethylimidazo[1,2-a]pyrimidin-3-yl)biphenyl-2-carbonitrile | HCID 9925268 | 44% |
Reaction Steps
3-Bromo-7-trifluoromethylimidazo[1,2-a]pyrimidine (0.28 g, 1.04 mmol) was coupled with 3′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile as described in Example 1 to give 3′-(7-trifluoromethylimidazo[1,2-a]pyrimidin-3-yl)biphenyl-2-carbonitrile (165 mg, 44%) as a yellow powder: δH (400 MHz, CDCl3) 7.29 (1H, d, J 7), 7.53 (1H, td, J 8 and 1), 7.59-7.68 (3H, m), 7.70-7.75 (2H, m), 7.80-7.85 (2H, m), 8.14 (1H, s), 9.20 (1H, d, J 7); m/z (ES+) 365 (M++H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06642229B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-063427371b06443987d9368b247abf3c |
| Source note | uspto-grants-2003_11 |