3'-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile → 3'-(7-Isopropylimidazo[1,2-a]pyrimidin-3-yl)biphenyl-2-carbonitrile

Participants

Reaction Steps

3-Bromo-7-isopropylimidazo[1,2-a]pyrimidine was coupled with 3′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile as described in Example 1 to give 3′-(7-isopropylimidazo[1,2-a]pyrimidin-3-yl)biphenyl-2-carbonitrile as a white powder: Found C, 76.71; H, 5.17; N 16.24. C22H18N4.0.3(H2O) requires C, 76.59; H, 5.43; N, 16.24; δH (400 MHz, CDCl3) 1.38 (6H, d, J 7), 3.16 (1H, septet, J 7), 6.88 (1H, d, J 7), 7.48-7.76 (7H, m), 7.82 (1H, dd, J 8 and 1), 7.85 (1H, s), 8.85 (1H, d, J 7); m/z (ES+) 339 (M++H).

Provenance & Evidence