HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanethiol → 3-{4-[2-(tert-Butoxycarbonyl-heptyl-amino)-ethyl]-phenyl}-2-ethylsulfanyl-propionic Acid Ethyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanethiol | HCID 6343 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 3-{4-[2-(Tert-butoxycarbonyl-heptyl-amino)-ethyl]-phenyl}-2-hydroxy-propionic acid ethyl ester | HCID 69883772 | — |
| Product | 3-{4-[2-(tert-Butoxycarbonyl-heptyl-amino)-ethyl]-phenyl}-2-ethylsulfanyl-propionic Acid Ethyl Ester | HCID 69884404 | — |
Reaction Steps
Synthesized from 3-{4-[2-(tert-butoxycarbonyl-heptyl-amino)-ethyl]-phenyl}-2-hydroxy-propionic acid ethyl ester using a procedure analogous to that used for Example 50 and substituting the sodium salt of ethanethiol as the nucleophile to give an approximate 1:1 mixture of ethyl and methyl ester as a clear film (23 mg, 43%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06699904B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-120af5db9851420fa573a4af83d2c3be |
| Source note | uspto-grants-2004_03 |