3'-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile → HCID 9946617, compound

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Reaction Steps

3-Bromoimidazo[1,2-a]pyrimidine-7-carboxylic acid methyl ester was coupled with 3′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile as described in Example 1 to give 3-(2′-cyanobiphenyl-3-yl)-imidazo[1,2-a]pyrimidine-7-carboxylic acid methyl ester as a pale yellow powder: δH (400 MHz, CDCl3) 4.07 (3H, s), 7.50-7.54 (1H, m), 7.58-7.76 (6H, m), 7.81-7.84 (2H, m), 8.18 (1H, s), 9.10 (1H, d, J 7); m/z (ES+) 355 (M++H).

Provenance & Evidence