2-(Trifluoromethyl)benzeneboronic acid → HCID 9946553, compound

Participants

Reaction Steps

Trifluoromethanesulfonic acid 3-(7-methylimidazo[1,2-a]pyrimidin-3-yl)phenyl ester (0.1 g, 0.28 mmol) was coupled to 2-trifluoromethylbenzeneboronic acid (52 μl, 0.59 mmol) as described in Example 21 to give 7-methyl-3-(2′-trifluoromethylbiphenyl-3-yl)-imidazo[1,2-a]pyrimidine as a white solid (35 mg): δH (400 MHz, CDCl3) 2.65 (3H, s), 6.77 (1H, d, J 7), 7.39 (1H, m), 7.48-7.62 (6H, m), 7.78 (1H, d, J 7.2), 7.82 (1H, s), 8.52 (1H, d, J 7); m/z (ES+) 354 (M++H).

Provenance & Evidence