2-Fluorophenylboronic acid → HCID 9879491, compound

Participants

Reaction Steps

Trifluoromethanesulfonic acid 3-(7-methylimidazo[1,2-a]pyrimidin-3-yl)phenyl ester (0.1 g, 0.28 mmol) was coupled to 2-fluorobenzene-boronic acid (52 μl, 0.59 mmol) as described in Example 21 to give 3-(2′-fluorobiphenyl-3-yl)-7-methylimidazo[1,2-a]pyrimidine as a white solid (104 mg): δH (400 MHz, CDCl3) 2.67 (3H, s), 6.78 (1H, d, J 7), 7.17-7.28 (2H, m), 7.37 (1H, m), 7.46-7.54 (2H, m), 7.60 (2H, m), 7.71 (1H, s), 7.85 (1H, s), 8.56 (1H,: d, J 7); m/z (ES+) 304 (M++H).

Provenance & Evidence