Stannous Chloride → 3'-Amino-4-fluorobiphenyl-2-carbonitrile

Participants

Reaction Steps

4-Fluoro-3′-nitrobiphenyl-2-carbonitrile was reduced by treatment with tin(II) chloride in ethanol and tetrahydrofuran to give 3′-amino-4-fluorobiphenyl-2-carbonitrile as a brown solid: δH (360 MHz, CDCl3) 6.76 (1H, ddd, J 8, 2 and 2), 6.80 (1H, dd, J 2 and 2), 6.87 (1H, ddd, J 8, 1 and 1), 7.27 (1H, dd, J 8 and 8), 7.35 (1H, ddd, J 8, 8 and 3), 7.41-7.51 (2H, m).

Provenance & Evidence