2-(3-Bromoimidazo[1,2-a]pyrimidin-7-yl)propan-2-ol → 4-Fluoro-3'-[7-(2-hydroxyprop-2-yl)imidazo[1,2-a]pyrimidin-3-yl]biphenyl-2-carbonitrile

Participants

Reaction Steps

2-(3-Bromoimidazo[1,2-a]pyrimidin-7-yl)propan-2-ol was coupled with 4-fluoro-3′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile as described in Example 1 to give 4-fluoro-3′-[7-(2-hydroxyprop-2-yl)imidazo[1,2-a]pyrimidin-3-yl]biphenyl-2-carbonitrile (260 mg, 70%) as a yellow powder: δH (360 MHz, CDCl3) 1.61 (6H, s), 4.51 (1H, s), 7.07 (1H, d, J 7), 7.45 (1H, ddd, J 8, 1 and 1), 7.51-7.60 (3H, m), 7.63-7.69 (2H, m), 7.73 (1H, s), 7.90 (1H, s), 8.94 (1H, d, J 7); m/z (ES+) 383 (M++H).

Provenance & Evidence