反应详情

A solution of Example 12A (0.98 g, 1.4 mmol) in methanol/methylene chloride (40 mL/10 mL) was degassed with nitrogen, treated with of 25% sodium methoxide in methanol (30 drops), stirred for 16 hours, filtered, and concentrated to a volume of 5 mL of methanol. The solid which had precipitated was collected by filtration, washed with methanol and dried under vacuum for 16 hours to provide the title compound (0.36 g).

1. filtrationfiltered
2. concentrationconcentrated to a volume of 5 mL of methanol
3. customThe solid which had precipitated
4. filtrationwas collected by filtration
5. washwashed with methanol
6. customdried under vacuum for 16 hours