HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-(3-Bromo-4-fluorophenyl)-5,8,9,10-tetrahydro-1h-pyrano[3,4-b][1,7]naphthyridine-4,6(3h,7h)-dione hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | vinyl 5-(3-bromo-4-fluorophenyl)-4,6-dioxo-4,5,6,7,9,10-hexahydro-1H-pyrano[3,4-b][1,7]naphthyridine-8(3H)-carboxylate | HCID 18000982 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(3-Bromo-4-fluorophenyl)-5,8,9,10-tetrahydro-1h-pyrano[3,4-b][1,7]naphthyridine-4,6(3h,7h)-dione hydrochloride | HCID 18000995 | — |
Reaction Steps
A solution of Example 24B in ethanol (10 mL) was treated with 6N HCl (5 mL), refluxed for 3 hours and concentrated. Purification by flash chromatography over silica gel (10% methanol/ammonia saturated methylene chloride) provided the title compound (0.080 g) which was converted to the hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06642222B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-58d2e4ad5c7548019bc21080076750f6 |
| Source note | uspto-grants-2003_11 |