反应详情

A solution of the product from Example 25B (0.16 g, 0.34 mmol) and 2M methyl amine in methanol (3.5 mL, 7.0 mmol) was stirred at ambient temperature for 16 hours and concentrated. Purification of the residue on silica gel (5% and then 10% methanol in methylene chloride) provided an oil which was crystallized from ethanol, collected by filtration and dried to yield the title compound (0.016 g) as a white solid.

1. concentrationconcentrated
2. customPurification of the residue on silica gel (5%
3. custom10% methanol in methylene chloride) provided an oil which
4. customwas crystallized from ethanol
5. filtrationcollected by filtration
6. customdried