反应详情

The product from Example 66C (1.5 g, 11 mmol) in ethanol (40 mL) was treated with concentrated sulfuric acid (0.4 mL), refluxed for 4 hours, cooled to ambient temperature, treated with 2M ammonia in ethanol (50 mL), stirred at ambient temperature for 16 hours and concentrated. The residue was purified by chromatography on silica gel eluting with 10% methanol in dichloromethane to provide the title compound (1.0 g).

1. temperaturerefluxed for 4 hours
2. concentrationconcentrated
3. customThe residue was purified by chromatography on silica gel eluting with 10% methanol in dichloromethane