HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-4-fluorobenzaldehyde → 5-(3-bromo-4-fluorophenyl)-3,3-dimethyl-5,7,8,9-tetrahydrocyclopenta[b]pyrano[4,3-e]pyridine-4,6(1H,3H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-4-fluorobenzaldehyde | HCID 173604 | — |
| Reactant | 3-Aminocyclopent-2-en-1-one | HCID 12291440 | — |
| Reactant | 2,2-dimethyl-2H-pyran-3,5(4H,6H)-dione | HCID 14072887 | — |
| Product | 5-(3-bromo-4-fluorophenyl)-3,3-dimethyl-5,7,8,9-tetrahydrocyclopenta[b]pyrano[4,3-e]pyridine-4,6(1H,3H)-dione | HCID 18000999 | 54.2% |
Reaction Steps
3-Amino-2-cyclopenten-1-one (Kikani, B. B., Synthesis, (1991), 2,176) (0.099 g, 1.0 mmol), 3-bromo-4-fluorobenzaldehyde (0.21 g, 1.0 mmol) and the product from Example 66C (0.15 g, 1.0 mmol) were processed as described in Example 31 to provide the title compound (0.22 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06642222B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-370d177f7f74469e8fb32fe5a43babdb |
| Source note | uspto-grants-2003_11 |