Methyl acetoacetate → HCID 18000970, compound

Participants

Reaction Steps

The product from Example 88D (0.50 g, 3.9 mmol), 3-bromo-4-fluorobenzaldehyde 0.96 g, 4.7 mmol) and methyl acetoacetate (0.46 g, 3.9 mmol) in ethanol (4 mL) was heated to 80° C. in a sealed tube for 60 hours, cooled to ambient temperature and concentrated. The residue was chromatographed on silica gel eluting with 1% and then 2% methanol in dichloromethane to provide the title compound (0.97 g).

Provenance & Evidence