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HRID 478311作成日:2026年10月25日

3-Bromo-4-fluorobenzaldehyde → 8-(3-Bromo-4-fluorophenyl)-11,11-dimethyl-5,12-dioxa-2-azatricyclo[7.4.0.03,7]trideca-1(9),3(7)-diene-6,10-dione

https://huagongshe.com/reaction/478311

反応式

関与物質

役割名称HCID仕込み量
反応物3-Bromo-4-fluorobenzaldehydeHCID 173604—
反応物Methyl 3-aminocrotonateHCID 643918—
反応物2,2-dimethyl-2H-pyran-3,5(4H,6H)-dioneHCID 14072887—
溶媒EthanolHCID 702—
生成物8-(3-Bromo-4-fluorophenyl)-11,11-dimethyl-5,12-dioxa-2-azatricyclo[7.4.0.03,7]trideca-1(9),3(7)-diene-6,10-dioneHCID 1027282721.7%

反応手順

The product from Example 66C (0.50 g, 3.5 mmol), 3-bromo-4-fluorobenzaldehyde (0.88 g, 4.2 mmol) and methyl 3-aminocrotonate (0.40 g, 3.5 mmol) in ethanol (5 mL) were processed as described in Example 71 to provide the title compound (0.31 g).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06642222B2
出典データセットuspto-grants-2003_11
ORD IDord-092df8400ef7405e832621207cce1c70
出典メモuspto-grants-2003_11