참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Fluorobenzonitrile | HCID 14517 | — |
| 반응물 | 4-Phenylpiperidine | HCID 69873 | — |
| 용매 | N-Methyl-2-piperidone | HCID 13603 | — |
| 생성물 | 4-Phenyl-1-(4-cyanophenyl)piperidine | HCID 18001056 | 48.7% |
반응 단계
4-Phenylpiperidine (0.5 g), p-fluorobenzonitrile (0.37 g) and potassium carbonate (0.78 g) are dissolved in N-methylpiperidone (5 ml), and the mixture is stirred at 120° C. for five hours. To the reaction solution is added ethyl acetate (50 ml), and the mixture is washed with water, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. To the resulting residue is added methanol, and the insoluble crystals are collected by filtration, dried under reduced pressure to give 4-phenyl-1-(4-cyanophenyl)piperidine (0.39 g) as white needles.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06642223B2 |
|---|
| 출처 데이터셋 | uspto-grants-2003_11 |
|---|
| ORD ID | ord-f449697ea4504b519345c50f84f86130 |
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| 출처 메모 | uspto-grants-2003_11 |
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