3,5-Bis(trifluoromethyl)benzoyl chloride → HCID 131724124, compound

HRID 478379Notes

Reaction equation

HRID 478379 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:11]=1)[C:6](Cl)=[O:7].Cl.[Br:19][C:20]1[CH:21]=[C:22]([C@H:26]2[CH2:31][CH2:30][NH:29][CH2:28][C@H:27]2[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:23]=[CH:24][CH:25]=1>>[F:1][C:2]([F:17])([F:16])[C:3]1[CH:4]=[C:5]([C:6]([N:29]2[CH2:30][CH2:31][C@H:26]([C:22]3[CH:23]=[CH:24][CH:25]=[C:20]([Br:19])[CH:21]=3)[C@H:27]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[CH2:28]2)=[O:7])[CH:9]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:11]=1

Participants

3

Reactant 2

HCID 1018563,5-Bis(trifluoromethyl)benzoyl chlorideHCID 131724125HCID 131724125, compound

Product 1

HCID 131724124HCID 131724124, compound

Procedure

The title compound, MS: m/e=556.0 (M+), was prepared in accordance with the general method of example 1 from 3,5-bis(trifluoromethyl)benzoyl chloride and rac-cis-4-(3-bromo-phenyl)-3-phenyl-piperidine hydrochloride.

Sources & evidence

ORD record
ord-7cd6a2811cc44f1e99f82ca481d01367
Source dataset
uspto-grants-2003_11
Patent number
US06642226B2

Reaction notes

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