Morpholine → HCID 131724153, compound

HRID 478403Notes

Reaction equation

HRID 478403 reaction equation
C([N:8]1[CH2:13][CH2:12][C:11](=O)[CH:10]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[Cl:21])[CH2:9]1)C1C=CC=CC=1.[NH:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1.[F:28][C:29]([F:44])([F:43])[C:30]1[CH:31]=[C:32]([CH:36]=[C:37]([C:39]([F:42])([F:41])[F:40])[CH:38]=1)[C:33](Cl)=[O:34]>>[F:28][C:29]([F:44])([F:43])[C:30]1[CH:31]=[C:32]([C:33]([N:8]2[CH2:13][CH2:12][C@H:11]([N:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)[C@H:10]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[Cl:21])[CH2:9]2)=[O:34])[CH:36]=[C:37]([C:39]([F:42])([F:41])[F:40])[CH:38]=1

Participants

4

Reactant 3

HCID 8083MorpholineHCID 1018563,5-Bis(trifluoromethyl)benzoyl chlorideHCID 18001174HCID 18001174, compound

Product 1

HCID 131724153HCID 131724153, compound

Procedure

The title compound, MS: m/e=521.1 (M+H+), was prepared in accordance with the general method of example 26 from 1-benzyl-3-(2-chloro-phenyl)-piperidin-4-one, morpholine and 3,5-bistrifluoromethyl-benzoyl chloride.

Sources & evidence

ORD record
ord-8c8b023dfb30463799a2891500c8760f
Source dataset
uspto-grants-2003_11
Patent number
US06642226B2

Reaction notes

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