2-Chloro-N-(2,6-dimethylphenyl)acetamide → HCID 131724169, compound

HRID 478418Notes

Reaction equation

HRID 478418 reaction equation
[F:1][C:2]([F:34])([F:33])[C:3]1[CH:4]=[C:5]([C:13]([N:15]2[CH2:20][CH2:19][C@H:18]([N:21]3[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)[C@H:17]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[CH2:16]2)=[O:14])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.Cl[CH2:36][C:37]([NH:39][C:40]1[C:45]([CH3:46])=[CH:44][CH:43]=[CH:42][C:41]=1[CH3:47])=[O:38]>>[F:34][C:2]([F:33])([F:1])[C:3]1[CH:4]=[C:5]([CH:6]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:8]=1)[C:13]([N:15]1[CH2:20][CH2:19][C@H:18]([N:21]2[CH2:26][CH2:25][N:24]([CH2:36][C:37]([NH:39][C:40]3[C:45]([CH3:46])=[CH:44][CH:43]=[CH:42][C:41]=3[CH3:47])=[O:38])[CH2:23][CH2:22]2)[C@H:17]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:16]1)=[O:14]

Participants

3

Reactant 2

HCID 707982-Chloro-N-(2,6-dimethylphenyl)acetamideHCID 131724158HCID 131724158, compound

Product 1

HCID 131724169HCID 131724169, compound

Procedure

The title compound, MS: m/e=647.2 (M+H+), was prepared in accordance with the general method of example 35 from rac-cis-(3,5-bis-trifluoromethyl-phenyl)-(3-phenyl-4-piperazin-1-yl-piperidin-1-yl)-methanone and N-chloroacetyl-2,6-dimethylaniline.

Sources & evidence

ORD record
ord-8e46cad051b84178b22ad0f23520b364
Source dataset
uspto-grants-2003_11
Patent number
US06642226B2

Reaction notes

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